- We will combine our current expertise and knowledge in microfluidics, nucleation and crystal growth to improve the efficiency and ease of crystallization of membrane proteins.
- We will create predictive models allowing us to identify the key parameters to be monitored in real time.
- We will develop novel miniaturized fluidic tools, and study how these, combined with better models of the phase diagram, allow better control of the kinetic pathways during crystallization.
- We will control the crystal size and crystal morphology during crystallizaion of membrane proteins.
- We will then confirm developped approaches by determining the structures (by X-ray and neutron crystallography) of the model membrane proteins, whose detailed analysis will validate the proof of concept for the structural study of therapeutic target membrane proteins.